Physician-Scientist
Uncovering how the innate immune system misfires in the lung — tracing STING-driven interferon disease from the bench to the bedside.
Focus
Trained as both physician and scientist, he works between the intensive-care unit and the laboratory bench — pairing clinical pulmonary and critical care medicine with the molecular study of how innate immunity defends the lung, and sometimes turns against it.
Research
In the Shum Lab, studying COPA syndrome and related disorders in which the sensor STING becomes inappropriately active — flooding the lung with type I interferon and driving interstitial lung disease.
Discovered how certain HIV-1 strains cloak their envelope in O-linked sugars — a glycan shield that hides the virus from a class of broadly neutralizing antibodies.
Software
Computational biology is a working method here, not a footnote. Between experiments, purpose-built software — for molecular cloning, colony management, and research automation.
Publications